Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type	Study_count
Total_Studies	2117
interventional	1829
Observational	282
Registry	6

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	677
Drug\|placebo	423
Behavioral	306
Other	115
Device	100
Behavioral\|Other	38
Behavioral\|Drug	25
Procedure	19
Drug\|Other	17
Dietary Supplement\|placebo	14
Behavioral\|Device	10
Dietary Supplement	10
Behavioral\|Drug\|placebo	9
Device\|placebo	9
Device\|Drug	5
Drug\|Other\|placebo	5
Drug\|Procedure	5
Combination Product	4
Other\|placebo	4
Biological	3
Genetic\|Other	3
Behavioral\|Drug\|Other	2
Behavioral\|Procedure	2
Device\|Other	2
Diagnostic Test	2
Genetic	2
Other\|Procedure	2
placebo	2
Behavioral\|Biological\|Diagnostic Test	1
Behavioral\|Device\|Drug	1
Behavioral\|Device\|placebo	1
Behavioral\|Diagnostic Test\|Other	1
Behavioral\|Drug\|Other\|placebo	1
Behavioral\|Drug\|placebo\|Radiation	1
Behavioral\|Drug\|Procedure	1
Behavioral\|Other\|Procedure	1
Combination Product\|Drug	1
Dietary Supplement\|Drug	1
Drug\|placebo\|Procedure	1
Drug\|Radiation	1
NA	1
placebo\|Procedure	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country	Study_Count
United States	757
NA	203
France	72
Canada	65
China	64
Germany	60
Taiwan	44
Spain	35
United Kingdom	35
Denmark	30
Korea, Republic of	27
Israel	25
Japan	25
Brazil	17
India	15
Hong Kong	14
Australia	13
Norway	12
Switzerland	8
Italy	7
Pakistan	6
Turkey	6
United States\|Puerto Rico	6
Egypt	5
Finland	5
Netherlands	5
United States\|Canada	5
Austria	4
Belgium	4
Ethiopia	4
Japan\|Korea, Republic of\|Taiwan	4
Sweden	4
Croatia	3
South Africa	3
United States\|Bulgaria\|Korea, Republic of\|Malaysia\|Philippines\|Romania\|Russian Federation\|Ukraine	3
United States\|India	3
Germany\|Switzerland	2
Iran, Islamic Republic of	2
Ireland	2
Israel\|Romania	2
Japan\|Korea, Republic of\|Malaysia\|Taiwan	2
Jordan	2
Malaysia	2
Mexico	2
Moldova, Republic of	2
Poland	2
Portugal	2
Tanzania	2
Thailand	2
United States\|Argentina\|Australia\|Colombia\|Finland\|France\|Hungary\|India\|Korea, Republic of\|Mexico\|Romania\|Russian Federation\|Sweden\|United Kingdom	2
United States\|Bulgaria	2
United States\|Bulgaria\|China\|Czech Republic\|Italy\|Japan\|Russian Federation	2
United States\|Bulgaria\|Latvia\|Russian Federation\|Serbia\|Ukraine	2
United States\|Bulgaria\|Serbia\|Ukraine	2
United States\|Croatia\|Latvia	2
United States\|Croatia\|Russian Federation	2
United States\|France\|Italy\|Russian Federation\|Serbia\|Slovakia\|South Africa	2
United States\|Hungary\|Romania\|Russian Federation\|Ukraine	2
United States\|India\|Romania\|Russian Federation\|Ukraine	2
United States\|Israel	2
United States\|Ukraine	2
Argentina	1
Argentina\|Austria\|Croatia\|Germany\|Mexico\|Portugal\|Romania\|Russian Federation\|South Africa	1
Argentina\|Brazil\|Germany\|Mexico\|Philippines\|Taiwan	1
Argentina\|Colombia	1
Argentina\|Croatia\|India\|Russian Federation\|Serbia\|Ukraine	1
Argentina\|Egypt\|Estonia\|France\|Greece\|Jordan\|Latvia\|Lebanon\|Lithuania\|Romania\|Slovakia\|South Africa\|Spain\|Turkey	1
Argentina\|Hong Kong\|Italy\|Poland\|Russian Federation\|Ukraine	1
Australia\|Austria\|Belgium\|Bulgaria\|Czechia\|Denmark\|France\|Germany\|Israel\|Italy\|Netherlands\|Poland\|Romania\|Spain\|Switzerland\|United Kingdom	1
Australia\|Austria\|Norway	1
Australia\|Belgium\|Brazil\|Croatia\|Czech Republic\|Mexico\|Slovakia\|Spain	1
Australia\|Canada\|Hong Kong\|Korea, Republic of	1
Australia\|China\|Hong Kong\|Korea, Republic of\|Malaysia\|New Zealand\|Philippines\|Taiwan\|Thailand	1
Austria\|Belgium\|Bulgaria\|Czechia\|Denmark\|Germany\|Greece\|Hungary\|Israel\|Italy\|Netherlands\|Norway\|Poland\|Romania\|Spain\|United Kingdom	1
Austria\|Belgium\|Bulgaria\|Germany\|Romania\|Spain	1
Austria\|Belgium\|Czech Republic\|France\|Germany\|Greece\|Hungary\|Italy\|Spain\|United Kingdom	1
Austria\|Czech Republic\|Denmark\|Finland\|France\|Germany\|Spain\|Sweden\|United Kingdom	1
Austria\|Czech Republic\|Finland\|France\|Germany\|Hungary\|Poland\|South Africa\|Sweden\|Switzerland\|Turkey\|United Kingdom	1
Austria\|Denmark\|Germany\|Italy\|Spain	1
Austria\|Norway	1
Belgium\|Brazil\|Bulgaria\|Costa Rica\|Finland\|Germany\|Italy\|Mexico\|Portugal\|Romania\|Russian Federation\|Spain\|Switzerland\|Turkey	1
Belgium\|Bulgaria\|Croatia\|Czech Republic\|Austria\|Egypt\|Estonia\|France\|Germany\|Greece\|Hungary\|Israel\|Jordan\|Korea, Republic of\|Lithuania\|Poland\|Romania\|Russian Federation\|Slovakia\|South Africa\|Spain\|Taiwan\|Turkey\|Ukraine\|United Kingdom	1
Belgium\|Bulgaria\|Croatia\|Denmark\|Finland\|France\|Germany\|Greece\|Hungary\|Israel\|Latvia\|Lithuania\|Netherlands\|Poland\|Portugal\|Russian Federation\|Serbia\|Spain\|Sweden\|Switzerland\|Turkey\|United Kingdom	1
Belgium\|France\|Germany\|Hong Kong\|Italy\|Poland\|Taiwan\|Thailand	1
Belgium\|France\|Netherlands\|Portugal\|Spain	1
Belgium\|Germany\|Russian Federation\|Slovakia\|Sweden	1
Belgium\|Netherlands	1
Brazil\|Chile	1
Brazil\|Colombia\|Mexico	1
Brazil\|Romania\|Turkey	1
Bulgaria	1
Bulgaria\|Croatia\|Czech Republic\|Austria\|Denmark\|Estonia\|France\|Germany\|Greece\|Hungary\|Ireland\|Israel\|Latvia\|Lithuania\|Poland\|Portugal\|Romania\|Saudi Arabia\|Slovakia\|Slovenia\|Spain\|Sweden\|Turkey\|United Kingdom	1
Bulgaria\|Czech Republic\|Germany\|Hungary\|Norway\|Romania\|Slovakia\|South Africa\|United Kingdom	1
Bulgaria\|Estonia\|Germany\|Hungary\|Latvia\|Poland\|Ukraine	1
Bulgaria\|Estonia\|Germany\|Hungary\|Latvia\|Ukraine	1
Bulgaria\|Greece\|India\|Indonesia\|Philippines\|Romania\|Russian Federation\|South Africa	1
Bulgaria\|Poland	1
Bulgaria\|United States\|Austria\|Belgium\|Chile\|Croatia\|Estonia\|France\|Hungary\|Italy\|Korea, Republic of\|Poland\|Puerto Rico\|South Africa\|Thailand	1
Canada\|Colombia\|Czech Republic\|France\|India\|Lithuania\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Ukraine	1
Canada\|Croatia\|Czech Republic\|France\|Hungary\|Netherlands\|Poland\|Romania\|Russian Federation\|South Africa\|United Kingdom	1
Canada\|Finland\|Germany\|Hungary	1
Canada\|Russian Federation	1
Canada\|United Kingdom	1
Chile	1
China\|Hong Kong	1
China\|Hong Kong\|Taiwan	1
China\|Japan\|Korea, Republic of\|Malaysia\|Philippines\|Russian Federation\|Taiwan\|Ukraine	1
China\|Korea, Republic of\|Malaysia\|Taiwan	1
Croatia\|Denmark\|France\|Germany\|Greece\|Israel\|Korea, Republic of\|Malaysia\|Netherlands\|Russian Federation\|Saudi Arabia\|Spain\|Taiwan\|Turkey\|United Kingdom	1
Croatia\|France\|Germany\|Israel\|Lithuania\|Poland\|Romania	1
Croatia\|United States\|Argentina\|Brazil\|Chile\|Israel\|South Africa\|Thailand	1
Czech Republic	1
Czech Republic\|Estonia\|Finland\|France\|Poland	1
Czech Republic\|France\|Hong Kong\|Indonesia\|Philippines\|Poland\|Spain\|Thailand	1
Czech Republic\|Germany\|Poland\|Slovakia\|United Kingdom	1
Czech Republic\|United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Bulgaria\|Canada\|China\|France\|Germany\|Greece\|Hungary\|Japan\|Korea, Republic of\|Mexico\|Poland\|Portugal\|Romania\|Russian Federation\|Slovakia\|Spain\|Sweden\|Taiwan\|Ukraine	1
Czechia\|Germany	1
Denmark\|Finland\|France\|Greece\|Israel\|Norway\|Slovenia\|Sweden\|Switzerland\|United Kingdom	1
Denmark\|Finland\|Iceland\|Switzerland	1
Denmark\|Germany	1
Egypt\|Greece\|Jordan\|Kuwait\|Lebanon\|Saudi Arabia\|South Africa\|Turkey\|United Arab Emirates	1
Finland\|Turkey	1
France\|Hungary\|Latvia\|Romania\|Russian Federation	1
France\|Monaco	1
France\|Switzerland	1
France\|Tunisia	1
Germany\|United Kingdom	1
Ghana	1
Greece	1
Hungary	1
Hungary\|Israel\|Spain	1
India\|Korea, Republic of\|United States\|Bulgaria\|Croatia\|Philippines\|Romania\|Russian Federation\|Serbia\|Slovakia\|Taiwan\|Ukraine	1
India\|United States\|Argentina\|Australia\|Bulgaria\|Chile\|Croatia\|Estonia\|Finland\|Hungary\|Korea, Republic of\|Malaysia\|Mexico\|Philippines\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Spain\|Taiwan\|Thailand	1
India\|United States\|Colombia\|Romania\|Russian Federation\|Ukraine	1
India\|United States\|Malaysia\|Russian Federation\|Ukraine	1
Ireland\|United Kingdom	1
Italy\|	1
Macedonia, The Former Yugoslav Republic of	1
Montenegro	1
Poland\|Romania\|United Kingdom	1
Poland\|United States\|Bulgaria\|Canada\|Czechia\|Estonia\|Finland\|Mexico\|Romania\|Russian Federation\|Serbia\|Slovakia\|Spain\|Ukraine	1
Poland\|United States\|Bulgaria\|Czechia\|Germany\|Italy\|Spain\|Ukraine	1
Puerto Rico	1
Romania\|United States\|Costa Rica\|Korea, Republic of\|Mexico\|Russian Federation\|South Africa\|Taiwan\|Ukraine	1
Russian Federation	1
Rwanda	1
Serbia	1
Singapore	1
Spain\|Serbia\|United States\|Bulgaria\|Canada\|Czechia\|Hungary\|Poland\|Russian Federation\|Ukraine	1
Spain\|United States\|Brazil\|Canada\|Chile\|Germany\|Latvia\|Lithuania\|Netherlands\|Poland\|Slovakia\|Taiwan\|Turkey\|Ukraine	1
Tunisia	1
Turkey\|Austria\|Belgium\|Croatia\|Denmark\|Estonia\|France\|Germany\|Greece\|Hungary\|Israel\|Latvia\|Lithuania\|Netherlands\|Portugal\|Spain\|Sweden\|Switzerland\|Ukraine\|United Kingdom	1
Uganda	1
Ukraine\|Bulgaria\|Estonia\|Korea, Republic of\|Lithuania\|Malaysia\|Romania\|Russian Federation\|South Africa\|Taiwan	1
Ukraine\|United States\|Bulgaria\|Russian Federation\|Serbia	1
Ukraine\|United States\|Russian Federation\|Serbia	1
United Kingdom\|United States\|Argentina\|Australia\|Brazil\|Colombia\|Italy\|Mexico\|Poland\|Romania\|Russian Federation\|Ukraine	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Brazil\|Croatia\|Czech Republic\|France\|Germany\|Hungary\|Israel\|Italy\|Mexico\|Netherlands\|Poland\|Portugal\|Puerto Rico\|Romania\|Russian Federation\|Slovakia\|South Africa\|Spain\|Sweden\|Taiwan	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Bulgaria\|Chile\|Croatia\|Estonia\|Finland\|France\|Hungary\|India\|Korea, Republic of\|Malaysia\|Mexico\|Norway\|Philippines\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Spain\|Taiwan\|Thailand	1
United States\|Argentina\|Australia\|Belgium\|Canada\|Colombia\|Germany\|Italy\|Mexico\|Poland\|Romania\|Russian Federation\|Singapore\|Spain\|Ukraine\|United Kingdom	1
United States\|Argentina\|Australia\|Brazil\|Bulgaria\|Czechia\|France\|Hong Kong\|Hungary\|India\|Italy\|Korea, Republic of\|Malaysia\|Mexico\|Poland\|Russian Federation\|South Africa\|Spain\|Taiwan\|Turkey\|Ukraine	1
United States\|Argentina\|Australia\|Brazil\|Canada\|Germany\|Mexico\|Poland\|Russian Federation\|Serbia\|Singapore\|Spain\|Ukraine	1
United States\|Argentina\|Austria\|Brazil\|Germany\|Ireland\|Mexico\|Peru\|Puerto Rico\|Spain\|United Kingdom\|Venezuela	1
United States\|Argentina\|Belgium\|Brazil\|Bulgaria\|Germany\|Spain	1
United States\|Argentina\|Brazil\|Canada\|France\|Greece\|Portugal\|Puerto Rico\|Romania\|Slovakia\|Spain\|Taiwan	1
United States\|Argentina\|Bulgaria\|India\|Malaysia\|Mexico\|Philippines\|Romania\|Russian Federation\|Serbia\|Slovakia\|Taiwan	1
United States\|Argentina\|Canada\|Czech Republic\|Estonia\|France\|Hungary\|Latvia\|Lithuania	1
United States\|Argentina\|Colombia\|Czech Republic\|Slovakia\|Ukraine	1
United States\|Argentina\|Russian Federation	1
United States\|Australia\|Bulgaria\|Canada\|Estonia\|Finland\|Germany\|Hungary\|Italy\|Latvia\|Lithuania\|Spain	1
United States\|Australia\|Canada\|France\|New Zealand\|United Kingdom	1
United States\|Austria\|Brazil\|France\|Germany\|Hungary\|Japan\|Mexico\|Poland\|Russian Federation	1
United States\|Austria\|Bulgaria\|Czech Republic\|Estonia\|France\|Germany\|Hungary\|India\|Lithuania\|Poland\|Russian Federation\|Spain\|Ukraine	1
United States\|Austria\|Bulgaria\|Ireland\|Israel\|Italy\|Poland\|Puerto Rico\|Serbia\|Ukraine\|United Kingdom	1
United States\|Austria\|Canada\|Germany\|Italy\|Japan\|Korea, Republic of\|Poland\|Spain\|Taiwan\|United Kingdom	1
United States\|Austria\|Germany\|Ireland\|Israel\|Italy\|Poland\|Spain\|Ukraine\|United Kingdom	1
United States\|Belgium\|Bulgaria\|Colombia\|France\|Hungary\|Korea, Republic of\|Malaysia\|Mexico\|Philippines\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Spain\|Ukraine\|United Kingdom	1
United States\|Belgium\|Bulgaria\|Croatia\|Israel\|Korea, Republic of\|Malaysia\|Slovakia\|South Africa\|Spain\|Taiwan	1
United States\|Belgium\|Bulgaria\|Estonia\|Finland\|India\|Korea, Republic of\|Poland\|Romania\|Russian Federation\|Ukraine	1
United States\|Belgium\|Costa Rica\|Czech Republic\|India\|Peru\|Russian Federation	1
United States\|Belgium\|Croatia\|Korea, Republic of\|Malaysia\|Poland\|Slovakia\|Spain\|Taiwan\|Thailand	1
United States\|Belgium\|Germany\|Greece\|Netherlands\|Poland	1
United States\|Brazil	1
United States\|Brazil\|Canada\|Chile\|Germany\|Latvia\|Lithuania\|Netherlands\|Poland\|Slovakia\|Spain\|Taiwan\|Turkey\|Ukraine	1
United States\|Brazil\|Germany\|Greece\|Spain\|Turkey	1
United States\|Brazil\|Israel\|Korea, Republic of\|Mexico\|Puerto Rico\|Russian Federation	1
United States\|Brazil\|Mexico	1
United States\|Brazil\|United Kingdom	1
United States\|Bulgaria\|Canada\|Czechia\|Estonia\|Mexico\|Poland\|Romania\|Russian Federation\|Serbia\|Slovakia\|Spain\|Ukraine	1
United States\|Bulgaria\|Canada\|Czechia\|Hungary\|Lithuania\|Poland\|Russian Federation\|Serbia\|Spain\|Ukraine	1
United States\|Bulgaria\|Canada\|Czechia\|Hungary\|Lithuania\|Poland\|Russian Federation\|Serbia\|Ukraine	1
United States\|Bulgaria\|Colombia\|France\|Hungary\|Korea, Republic of\|Malaysia\|Mexico\|Philippines\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Spain\|Ukraine	1
United States\|Bulgaria\|Croatia\|India\|Korea, Republic of\|Philippines\|Romania\|Russian Federation\|Serbia\|Slovakia\|Taiwan\|Ukraine	1
United States\|Bulgaria\|Czech Republic	1
United States\|Bulgaria\|Korea, Republic of\|Malaysia\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Serbia\|Taiwan\|Thailand\|Ukraine	1
United States\|Bulgaria\|Poland	1
United States\|Bulgaria\|Poland\|Ukraine	1
United States\|Canada\|Colombia\|Croatia\|Japan\|Korea, Republic of\|Latvia\|Malaysia\|Mexico\|Philippines\|Poland\|Puerto Rico\|Romania\|Russian Federation\|Serbia\|Slovakia\|Taiwan\|Turkey\|Ukraine	1
United States\|Canada\|France\|Japan\|Korea, Republic of\|Spain\|Taiwan	1
United States\|Canada\|Germany\|Japan\|Taiwan	1
United States\|Canada\|Japan\|Korea, Republic of\|Latvia\|Poland\|Romania\|Serbia\|Ukraine	1
United States\|Canada\|Mexico\|Netherlands\|Puerto Rico	1
United States\|Canada\|United Kingdom	1
United States\|China	1
United States\|China\|Israel	1
United States\|Colombia\|Croatia\|Mexico\|Philippines\|Russian Federation\|Slovakia\|Taiwan	1
United States\|Colombia\|India\|Lithuania\|Philippines	1
United States\|Colombia\|India\|Romania\|Russian Federation\|Ukraine	1
United States\|Colombia\|India\|South Africa	1
United States\|Colombia\|Korea, Republic of\|Malaysia\|Mexico\|Romania\|Turkey\|Ukraine	1
United States\|Colombia\|Malaysia\|Puerto Rico\|Romania\|Serbia\|Turkey\|Ukraine	1
United States\|Colombia\|Romania\|Russian Federation\|Slovakia\|Ukraine	1
United States\|Estonia\|Poland\|Romania\|Russian Federation\|Serbia\|Slovakia\|Ukraine	1
United States\|France\|India\|Malaysia\|Romania\|Russian Federation\|Ukraine	1
United States\|Germany\|India\|Malaysia\|Philippines\|Poland\|Russian Federation\|Serbia\|South Africa\|Ukraine	1
United States\|Germany\|Mexico\|Russian Federation	1
United States\|Germany\|Ukraine	1
United States\|Greece	1
United States\|Hungary\|Romania\|Russian Federation\|Serbia\|Ukraine	1
United States\|India\|Malaysia\|Moldova, Republic of\|Philippines	1
United States\|India\|Malaysia\|Philippines\|Poland\|Russian Federation\|Serbia\|South Africa\|Ukraine	1
United States\|India\|Malaysia\|Philippines\|Romania\|Russian Federation\|Taiwan	1
United States\|India\|Malaysia\|Russian Federation\|Ukraine	1
United States\|India\|Romania	1
United States\|India\|Romania\|Russian Federation\|Slovakia\|Spain\|Ukraine	1
United States\|India\|Romania\|Slovakia\|Ukraine	1
United States\|India\|Russian Federation\|Ukraine	1
United States\|India\|Taiwan	1
United States\|India\|Ukraine	1
United States\|Israel\|Italy\|Spain	1
United States\|Japan	1
United States\|Korea, Republic of\|Malaysia\|Romania\|Russian Federation\|Serbia\|Taiwan\|Ukraine	1
United States\|Mexico	1
United States\|Poland\|Puerto Rico\|Russian Federation	1
United States\|Puerto Rico\|Russian Federation	1
United States\|Romania\|Russian Federation\|Slovakia\|Ukraine	1
United States\|Romania\|Russian Federation\|Ukraine	1
United States\|Russian Federation	1
United States\|Russian Federation\|Ukraine	1
United States\|Russian Federation\|United Kingdom	1
United States\|Taiwan	1
Vietnam	1

Sites per Study

Site_count	Study_Count
1	1200
2	152
3	47
4	41
5	26
6	22
7	13
8	24
9	11
10	7
11	8
12	10
13	6
14	6
15	11
16	10
17	7
18	3
19	2
20	10
21	8
22	8
23	3
24	6
25	3
26	6
27	7
28	4
29	5
30	2
31	7
32	4
33	6
34	4
35	4
36	2
37	4
38	2
39	4
41	3
42	5
43	5
44	1
45	3
46	5
48	6
49	4
50	1
51	1
52	2
53	1
54	4
55	1
56	3
57	4
58	1
59	1
60	3
61	3
62	1
63	1
64	3
65	5
66	2
67	1
69	2
71	2
72	2
73	4
74	2
75	1
76	1
80	1
81	1
82	1
83	1
84	1
86	1
87	2
88	1
90	2
92	1
94	1
98	2
99	1
101	1
102	1
103	1
106	1
107	1
110	1
113	1
116	1
117	1
120	1
122	3
124	1
129	2
138	1
141	1
147	1
148	1
157	1
177	1
214	1
236	1

Phase

Phase	Study_Count
N/A	671
Phase 4	335
Phase 3	296
Phase 2	233
Phase 1	208
Phase 2/Phase 3	42
Phase 1/Phase 2	30
Early Phase 1	14

Number of Arms

Number_of_Arms	Count_of_Studies
1	268
2	895
3	242
4	107
5	21
6	11
7	5
8	7
9	2
10	1
12	2
NA	268

Number of Updates

Count of Versions	Count of Studies
1	141
2	202
3	233
4	224
5	167
6	136
7	121
8	86
9	82
10	68
11	42
12	51
13	31
14	22
15	20
16	24
17	14
18	15
19	14
20	13
21	5
22	7
23	10
24	8
25	3
26	5
27	4
28	4
29	6
30	3
31	3
32	4
33	5
34	5
35	4
36	5
37	3
38	3
39	1
40	3
41	4
43	1
44	4
45	1
46	1
47	1
48	2
50	1
51	1
53	1
54	1
56	1
57	2
58	1
59	1
70	1
76	1
80	1
82	1
83	1
85	1
86	1
102	1
106	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	12817	1688	7.593009
Contacts/Locations	5819	1424	4.086376
Recruitment Status	2600	1440	1.805556
Study Design	2154	1283	1.678878
None (earliest Version on record)	1829	1829	1.000000
Outcome Measures	1591	946	1.681818
Sponsor/Collaborators	1445	830	1.740964
Arms	1282	825	1.553939
Interventions	1282	825	1.553939
Study Identification	1264	749	1.687583
Eligibility	1161	739	1.571042
Study Description	1126	702	1.603989
Oversight	843	686	1.228863
References	700	377	1.856764
More Information	421	221	1.904977
Results	390	390	1.000000
Conditions	373	296	1.260135
IPDSharing	195	178	1.095506
Baseline Characteristics	150	124	1.209677
Results Submission Events	112	112	1.000000
Reported Adverse Events	85	75	1.133333
Participant Flow	75	68	1.102941
Documents	57	52	1.096154
2020 Study Status	1	1	1.000000
Quality Control Review has not concludedReturned: June 23	1	1	1.000000

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	2.0000	1.0000	4.00000	10.00000	5.0000	0.0000	1.0000	10.0000
1st Qu.	33.5000	38.0000	24.00000	31.00000	40.0000	45.0000	120.0000	40.0000
Median	55.0000	69.0000	40.00000	49.00000	86.0000	72.0000	300.0000	79.0000
Mean	260.0714	132.4857	54.40887	59.24138	141.6987	126.3171	386.7201	202.4377
3rd Qu.	73.7500	120.0000	65.00000	75.00000	220.0000	161.0000	493.0000	198.0000
Max.	2700.0000	10347.0000	328.00000	160.00000	880.0000	512.0000	9809.0000	18239.0000

Trial Group Type

group_type	Group_Count
Experimental	1812
Active Comparator	795
Placebo Comparator	532
NA	268
Other	154
No Intervention	127
Sham Comparator	106

Intervention Model

intervention_model	Study_Count
Parallel Assignment	1259
Single Group Assignment	351
Crossover Assignment	167
Factorial Assignment	29
NA	16
Sequential Assignment	7

Primary Purpose

primary_purpose	Study_Count
Treatment	1434
Basic Science	95
Other	68
NA	60
Prevention	47
Health Services Research	46
Supportive Care	45
Diagnostic	29
Screening	4
Device Feasibility	1

Observational Studies

Studies by Country

Country	Study_Count
United States	87
NA	38
France	17
Spain	15
Korea, Republic of	14
China	10
Canada	9
Taiwan	7
Israel	6
Norway	6
Denmark	5
Italy	5
Netherlands	5
Belgium	4
Greece	4
Croatia	3
Germany	3
Hong Kong	3
Hungary	3
Russian Federation	2
Switzerland	2
Thailand	2
Turkey	2
United States\|Canada	2
Australia	1
Australia\|Czech Republic\|France\|Italy\|Russian Federation\|Spain\|Turkey	1
Austria	1
Austria\|Finland\|Germany\|Netherlands	1
Belgium\|France\|Germany\|Hungary\|Italy\|Spain\|United Kingdom	1
Brazil\|Mexico	1
Bulgaria	1
Canada\|Czech Republic\|Denmark\|Kazakhstan\|Sweden\|Thailand\|Ukraine	1
Croatia\|Russian Federation\|Turkey	1
Egypt\|Saudi Arabia\|United Arab Emirates	1
France\|Germany\|Greece	1
France\|Germany\|Italy\|Spain	1
Germany\|Belgium\|Bulgaria\|Denmark\|Greece\|Israel\|Kazakhstan\|Russian Federation	1
Germany\|Greece\|Netherlands\|Spain	1
Hungary\|Latvia\|Romania	1
India	1
Italy\|Argentina\|Brazil\|Canada\|France\|Germany\|Spain\|United Kingdom	1
Latvia	1
Portugal	1
Romania	1
Singapore	1
Slovenia	1
Sweden	1
Turkey\|Czech Republic\|France\|Germany\|Greece\|Russian Federation\|South Africa\|Spain	1
United Kingdom	1
United States\|Australia	1
United States\|Canada\|Israel\|Singapore\|United Kingdom	1
United States\|France\|Russian Federation	1

Sites per Study

Site_count	Study_Count
1	197
2	10
3	8
4	5
5	1
6	5
7	5
8	2
9	1
10	3
11	3
12	1
13	1
14	4
15	2
16	1
17	2
18	2
19	1
20	2
24	1
25	2
32	1
33	2
34	2
35	1
37	1
39	1
41	1
43	1
44	1
46	1
48	1
52	1
53	1
57	1
61	1
65	1
67	1
88	1
99	1
107	1
148	1

Number of Updates

Count of Versions	Count of Studies
1	25
2	28
3	42
4	38
5	30
6	22
7	12
8	13
9	9
10	7
11	6
12	1
13	4
14	4
15	2
16	4
17	2
18	2
22	3
23	2
24	1
25	1
26	1
27	1
30	1
31	1
32	2
34	2
37	1
39	1
56	1
59	1
67	1
76	1
89	1
96	2
123	1
125	1
126	1
132	1
170	1
172	1
189	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	3105	257	12.081712
Contacts/Locations	783	208	3.764423
Study Description	570	96	5.937500
Study Design	385	193	1.994819
Recruitment Status	335	204	1.642157
None (earliest Version on record)	282	282	1.000000
Eligibility	218	112	1.946429
Sponsor/Collaborators	170	116	1.465517
Study Identification	123	78	1.576923
Outcome Measures	122	87	1.402299
Oversight	109	77	1.415584
Groups	100	68	1.470588
Interventions	100	68	1.470588
References	96	41	2.341463
Conditions	59	41	1.439024
IPDSharing	15	13	1.153846
Results	10	10	1.000000
More Information	5	4	1.250000
Baseline Characteristics	3	3	1.000000
Documents	3	3	1.000000
Participant Flow	2	2	1.000000
Reported Adverse Events	2	2	1.000000
Results Submission Events	2	2	1.000000

Enrollment Metrics

Measure	Observational
Min	1.000
1st Qu	72.000
Median	193.000
Mean	6555.119
3rd Qu	595.250
Max	751725.000

Observation Model

observational_model	Study_Count
Cohort	96
NA	56
Case-Only	43
Case-Control	33
Case Control	19
Other	12
Defined Population	8
Ecologic or Community	6
Family-Based	6
Defined Population, Natural History	2
Case-Crossover	1

Time Perspective

time_perspective	Study_Count
Prospective	156
Cross-Sectional	51
Retrospective	31
NA	18
Other	15
Longitudinal, Retrospective/Prospective	6
Cross-Sectional, Prospective	2
Cross-Sectional, Retrospective	2
Longitudinal, Prospective	1

Registries

Studies by Country

Country	Study_Count
China	3
United States	2
Spain	1

Sites per Study

Site_count	Study_Count
1	6

Number of Updates

Count of Versions	Count of Studies
1	1
2	1
3	1
4	1
11	1
16	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	31	5	6.200000
Sponsor/Collaborators	12	2	6.000000
Contacts/Locations	11	3	3.666667
None (earliest Version on record)	6	6	1.000000
Study Description	5	2	2.500000
Outcome Measures	4	4	1.000000
References	4	1	4.000000
Eligibility	3	2	1.500000
Recruitment Status	3	2	1.500000
Study Design	3	2	1.500000
Groups	2	1	2.000000
Interventions	2	1	2.000000
IPDSharing	2	2	1.000000
Conditions	1	1	1.000000
Oversight	1	1	1.000000

Enrollment Metrics

Measure	Registries
Min	30.000
1st Qu	144.250
Median	538.500
Mean	1217.833
3rd Qu	2075.000
Max	3600.000

Registry Model

observational_model	Study_Count
Case-Control	3
Cohort	2
Case-Only	1

Time Perspective

time_perspective	Study_Count
Prospective	5
Cross-Sectional	1

Follow-up

target_duration	Study_Count
8 Weeks	3
15 Months	1
2 Days	1
24 Months	1

intervention_type	Study_Count
Drug	677
Drug\|placebo	423
Behavioral	306
Other	115
Device	100
Behavioral\|Other	38
Behavioral\|Drug	25
Procedure	19
Drug\|Other	17
Dietary Supplement\|placebo	14
Behavioral\|Device	10
Dietary Supplement	10
Behavioral\|Drug\|placebo	9
Device\|placebo	9
Device\|Drug	5
Drug\|Other\|placebo	5
Drug\|Procedure	5
Combination Product	4
Other\|placebo	4
Biological	3
Genetic\|Other	3
Behavioral\|Drug\|Other	2
Behavioral\|Procedure	2
Device\|Other	2
Diagnostic Test	2
Genetic	2
Other\|Procedure	2
placebo	2
Behavioral\|Biological\|Diagnostic Test	1
Behavioral\|Device\|Drug	1
Behavioral\|Device\|placebo	1
Behavioral\|Diagnostic Test\|Other	1
Behavioral\|Drug\|Other\|placebo	1
Behavioral\|Drug\|placebo\|Radiation	1
Behavioral\|Drug\|Procedure	1
Behavioral\|Other\|Procedure	1
Combination Product\|Drug	1
Dietary Supplement\|Drug	1
Drug\|placebo\|Procedure	1
Drug\|Radiation	1
NA	1
placebo\|Procedure	1

Count of Versions	Count of Studies
1	141
2	202
3	233
4	224
5	167
6	136
7	121
8	86
9	82
10	68
11	42
12	51
13	31
14	22
15	20
16	24
17	14
18	15
19	14
20	13
21	5
22	7
23	10
24	8
25	3
26	5
27	4
28	4
29	6
30	3
31	3
32	4
33	5
34	5
35	4
36	5
37	3
38	3
39	1
40	3
41	4
43	1
44	4
45	1
46	1
47	1
48	2
50	1
51	1
53	1
54	1
56	1
57	2
58	1
59	1
70	1
76	1
80	1
82	1
83	1
85	1
86	1
102	1
106	1

Site_count	Study_Count
1	197
2	10
3	8
4	5
5	1
6	5
7	5
8	2
9	1
10	3
11	3
12	1
13	1
14	4
15	2
16	1
17	2
18	2
19	1
20	2
24	1
25	2
32	1
33	2
34	2
35	1
37	1
39	1
41	1
43	1
44	1
46	1
48	1
52	1
53	1
57	1
61	1
65	1
67	1
88	1
99	1
107	1
148	1

Count of Versions	Count of Studies
1	25
2	28
3	42
4	38
5	30
6	22
7	12
8	13
9	9
10	7
11	6
12	1
13	4
14	4
15	2
16	4
17	2
18	2
22	3
23	2
24	1
25	1
26	1
27	1
30	1
31	1
32	2
34	2
37	1
39	1
56	1
59	1
67	1
76	1
89	1
96	2
123	1
125	1
126	1
132	1
170	1
172	1
189	1

Count of Versions	Count of Studies
1	141
2	202
3	233
4	224
5	167
6	136
7	121
8	86
9	82
10	68
11	42
12	51
13	31
14	22
15	20
16	24
17	14
18	15
19	14
20	13
21	5
22	7
23	10
24	8
25	3
26	5
27	4
28	4
29	6
30	3
31	3
32	4
33	5
34	5
35	4
36	5
37	3
38	3
39	1
40	3
41	4
43	1
44	4
45	1
46	1
47	1
48	2
50	1
51	1
53	1
54	1
56	1
57	2
58	1
59	1
70	1
76	1
80	1
82	1
83	1
85	1
86	1
102	1
106	1

Site_count	Study_Count
1	197
2	10
3	8
4	5
5	1
6	5
7	5
8	2
9	1
10	3
11	3
12	1
13	1
14	4
15	2
16	1
17	2
18	2
19	1
20	2
24	1
25	2
32	1
33	2
34	2
35	1
37	1
39	1
41	1
43	1
44	1
46	1
48	1
52	1
53	1
57	1
61	1
65	1
67	1
88	1
99	1
107	1
148	1

Count of Versions	Count of Studies
1	25
2	28
3	42
4	38
5	30
6	22
7	12
8	13
9	9
10	7
11	6
12	1
13	4
14	4
15	2
16	4
17	2
18	2
22	3
23	2
24	1
25	1
26	1
27	1
30	1
31	1
32	2
34	2
37	1
39	1
56	1
59	1
67	1
76	1
89	1
96	2
123	1
125	1
126	1
132	1
170	1
172	1
189	1

schizophrenia

Study Counts

Studies over Time

Interventional Trials

Intervention Type

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Studies by Country

Sites per Study

Phase

Number of Arms

Number of Updates

Update History Change Type

Enrollment Metrics by Phase

Trial Group Type

Intervention Model

Primary Purpose

Observational Studies

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Observation Model

Time Perspective

Registries

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Registry Model

Time Perspective

Follow-up

Count of Versions	Count of Studies
1	141
2	202
3	233
4	224
5	167
6	136
7	121
8	86
9	82
10	68
11	42
12	51
13	31
14	22
15	20
16	24
17	14
18	15
19	14
20	13
21	5
22	7
23	10
24	8
25	3
26	5
27	4
28	4
29	6
30	3
31	3
32	4
33	5
34	5
35	4
36	5
37	3
38	3
39	1
40	3
41	4
43	1
44	4
45	1
46	1
47	1
48	2
50	1
51	1
53	1
54	1
56	1
57	2
58	1
59	1
70	1
76	1
80	1
82	1
83	1
85	1
86	1
102	1
106	1

Site_count	Study_Count
1	197
2	10
3	8
4	5
5	1
6	5
7	5
8	2
9	1
10	3
11	3
12	1
13	1
14	4
15	2
16	1
17	2
18	2
19	1
20	2
24	1
25	2
32	1
33	2
34	2
35	1
37	1
39	1
41	1
43	1
44	1
46	1
48	1
52	1
53	1
57	1
61	1
65	1
67	1
88	1
99	1
107	1
148	1

Count of Versions	Count of Studies
1	25
2	28
3	42
4	38
5	30
6	22
7	12
8	13
9	9
10	7
11	6
12	1
13	4
14	4
15	2
16	4
17	2
18	2
22	3
23	2
24	1
25	1
26	1
27	1
30	1
31	1
32	2
34	2
37	1
39	1
56	1
59	1
67	1
76	1
89	1
96	2
123	1
125	1
126	1
132	1
170	1
172	1
189	1